For Better Health
Askdocweb is about side effects
Search for
Online since 2002
Home star Site Map star Resources star Contact Us star Privacy Policy star Advertise


Natural health supplements sometimes have unexpected side effects or interactions with medication that can lead to adverse reactions that are sometimes life threatening. The following is a list of cautions that you should be aware of before using creatine (methyl guanidine-acetic acid). These are referred to as drug/herb interactions.

Warning 1 - Contraindications: Kidney disease.

Warning 2 - Glucose: May increase the storage of creatine in muscle tissue.

Warning 3 - Caffeine: Drinking coffee and soft drinks that contain caffeine may decrease the effects of creatine.

Warning 4 - Asthma: The Mayo Clinic states that creatine has been associated with asthmatic symptoms and warns against consumption by persons with known allergies.

Warning 5 - Nephrotoxic Drugs: Taking high doses of creatine with medications that can harm the kidneys might increase the chance of kidney damage. Drugs in this class include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak), and tobramycin (Nebcin); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.

Used as a natural herbal medicine creatine has been used for the following benefits and conditions:
  • Enhance physical performance and ability
  • Gain strength
  • Build muscle mass
  • Gain weight
  • Creatine has been demonstrated to cause modest increases in strength in people with a variety of neuromuscular disorders.
  • Improved cognitive ability
  • May slow the worsening of some symptoms in people with early Parkinson?s disease.
  • Slows the loss of sight from gyrate atrophy.
  • There is some evidence that taking a high-dose creatine daily may increase exercise capacity and decrease muscle pain caused by exercise in some patients with McArdle's disease.

Side Effects of Creatine

Creatine appears to be generally safe, although taken in large amounts there is the potential for kidney damage. Extensive research over the last decade has shown that oral creatine supplementation at a rate of 5 to 20 grams per day appears to be very safe. The most commonly reported side effects of creatine supplementation are
  1. diarrhea
  2. muscle cramping
Other side effects may also occur when using creatine. (See form below)

Return to the Herb List.

For questions and answers about the side effects of herbs see the Herb Forum

Related Articles

If you find this page useful share it with others. Use the form below to add a side effect not listed or comments about creatine. Please note that all addresses are held confidential.

Thanks for stopping by.

Your name:
Your email:

What herbal medicine do you use?


This consumer advocate website is protected by copyright 2011-2012 Askdocweb, Inc. All Rights Reserved. This is a layman's report on creatine and is not intended to replace discussions with a health care provider. Do not use the information on this forum as a substitute for your doctor's advice. Always consult your doctor before taking any drug and follow your doctor's directions. Source material: Food and Drug Administration, Medline, Physician's Desk Reference, and the largest community of people in the world, those who are concerned about side effects and healthcare.
Bottom of page